I have been on just about every drug for depression over the past years.I haave been on Wellbutrin for three weeks and a couple of hours ago started feeling that manic feeling, and my muscles tightening up, gritting my teeth and feeling unsettled.I have also experienced more involuntary mucle jerking.

Grace

Grace,

Some of the side effects you should be looking for if you just started taking Wellbutrin are: mood changes, anxiety, panic attacks, trouble sleeping, irritability, agitation, aggressiveness, severe restlessness, mania (mental and/or physical hyperactivity), or thoughts of suicide or hurting yourself. If you are taking Wellbutrin for these specific issues, and they are getting worse, OR, if they just started now that you are on Wellbutrin CONTACT YOUR DOCTOR. If you experience any of these side effects in the first 12 weeks of your Wellbutrin treatment, CONTACT A DOCTOR!

Read this Wellbutrin Medications Guide at Wellbutrin.com to learn more about the drug you are currently on. [PDF File]

Stefford

i too have been on a number of drugs since my youth. i have been on lithium, lexapro, and wellbutrin for some time now. recently my dosage was upped to 450 a day. i too get the manic feeling and the muscle jerking. the manic feeling is almost like nothing can provide solace from boredom. it's maddening. it doesn't happen every day, but it does happen. the muscle jerking is involuntary almost like a spasm. my doctor had said the muscle jump was from my lithium. not so sure about that after reading your symptoms. i also get hand tremors occasionally. nothing debilitating though. my suggestions are to try different times of taking your pill to see what works better. the muscle jumps get better. as far as the manic episodes, it drives me crazy. my wife too. in time these will lessen, i believe, as your body gets used to the drug. but obviously if it keeps up, consult your doctor. maybe he'll give you a smaller dosage or two small doses throughout the day. good luck. once you get it right, it works preety well.

My daughter started on 150mg Wellbutrin about 2 weeks ago and then one week later it was increased to 300mg. She start having muscle and joint pain and that stopped after a few days. Now she has had terrible headaches and throwing up. She is manic and has made a couple of bad choices that is out of her character normally.

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