You can utilize the Interactions cross-check database at
Drug Digest to check this info.
S-ADENOSYL METHIONINE (SAM-E) (in SAM) may interact with VENLAFAXINE HYDROCHLORIDE (in Effexor)
1 potential interaction was found for the drugs you selected.
Both SAM-e and venlafaxine, a drug used mainly to treat depression, may increase the body's supplies of a neurotransmitter known as serotonin. Neurotransmitters are natural chemicals that carry signals from nerve cells to other cells in the body. An excess of serotonin is rare, but it could potentially cause "serotonin syndrome", a set of serious effects such as confusion, hallucinations, shaking, seizures, coma, and even death. Although the risk of serotonin syndrome is slight, SAM-e should not be taken with venlafaxine. Ask your healthcare provider about these drugs and this potential interaction as soon as possible.
This interaction is poorly documented and is considered moderate in severity.SL