Don't listen to the first Guest reply. That guy sounds like an imbecile.
You can take shrooms (psilocybin) on Wellbutrin (bupropion) but take a lot less than you normally do. It makes the experience a lot more intense.
As for Ecstasy (MDMA), some people say that on Wellbutrin, Ecstasy doesn't seem to work at all. This is dangerous because some people might take a lot thinking the pills are weak.. this is dangerous.
Other people report that Ecstasy isn't affected at all, and others say that E is way more intense on Wellbutrin.
If you're prone to seizures, I don't recommend taking E on Wellbutrin, but if you decide to, start off at a very low dose. If nothing happens, I don't suggest trying more, because it's likely just not going to work.
The reason people have such varied reports with Wellbutrin + MDMA might be due to different dosages, different ways the drugs affect people, or maybe because some of the people reporting this are feeling effects from something mixed in with street Ecstasy.
Due to the fact that street MDMA is adultrated, I would advise not taking E on Wellbutrin.. while a sober person can handle cut/laced drugs just fine, you might have a bad reaction with Wellbutrin + the drug the E is cut with.
Either way, start off at a VERY low dose if you do decide to roll (1/4 pill) and take more gradually. Stay safe <3